INCREASED INTERACTIONS AND ENGULFMENT OF DENDRITES BY MICROGLIA PRECEDE PURKINJE CELL DEGENERATION IN A MOUSE MODEL OF NIEMANN PICK TYPE-C

Increased interactions and engulfment of dendrites by microglia precede Purkinje cell degeneration in a mouse model of Niemann Pick Type-C

Abstract Niemann Pick Type-C disease (NPC) is an inherited lysosomal storage disease (LSD) caused by pathogenic variants in the Npc1 or Npc2 genes that lead to the accumulation of cholesterol and lipids in lysosomes.NPC1 deficiency causes neurodegeneration, dementia and early death.Cerebellar Purkinje cells (PCs) are particularly hypersensitive to

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Utility of in silico-identified-peptides in spike-S1 domain and nucleocapsid of SARS-CoV-2 for antibody detection in COVID-19 patients and antibody production

Abstract SARS-CoV-2 contains four structural proteins, two of which, the spike and nucleocapsid, are commonly used for the standardization of novel methods for antibody detection; however, some limitations in their use have been observed due to the homology of this virus with other phylogenetically-related viruses.We performed in silico analysis to

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Public comment sentiment on educational videos: Understanding the effects of presenter gender, video format, threading, and moderation on YouTube TED talk comments.

Scholars, educators, and students are increasingly encouraged to participate in online spaces.While the current literature highlights the potential positive outcomes of Warranty such participation, little research exists on the sentiment that these individuals may face online and on the factors that may lead some people to face different types of s

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Factors associated with exclusive breastfeeding at discharge during the COVID-19 pandemic in 17 WHO European Region countries

Abstract Background Exclusive breastfeeding is the optimal infant nutrition, providing infants immunoprotection against many diseases including SARS-CoV-2 infection.Restrictions during the COVID-19 pandemic may have negatively affected breastfeeding practices in maternity care facilities.The aims of the study were to examine exclusive breastfeeding

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